Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder

@inproceedings{Labont2014EpigeneticMO,
  title={Epigenetic modulation of glucocorticoid receptors in posttraumatic stress disorder},
  author={Benoit Labont{\'e} and Nelson Azoulay and Volodymyr Yerko and Gustavo Turecki and Alain Brunet},
  booktitle={Translational Psychiatry},
  year={2014}
}
Some individuals suffering from posttraumatic stress disorder (PTSD) exhibit lower basal salivary cortisol and higher glucocorticoid receptor (GR) sensitivity. Recent studies suggest that epigenetic mechanisms regulate the activity of cortisol and GR. As a means to combine and cross-validate those findings, we compared cortisol, GR expression and promoter methylation levels in peripheral T lymphocytes of healthy controls versus individuals endorsing a diagnosis of lifetime PTSD. Thirty subjects… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS