Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation.

@article{Sikorska2008EpigeneticMO,
  title={Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation.},
  author={Marianna Sikorska and Jagdeep K Sandhu and Paromita Deb-Rinker and Anna Jezierski and Julie E Leblanc and Claudie Charlebois and Maria Ribecco-Lutkiewicz and Mahmud Bani-Yaghoub and P. Roy Walker},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 8},
  pages={
          1680-93
        }
}
SOX2 is a key neurodevelopmental gene involved in maintaining the pluripotency of stem cells and proliferation of neural progenitors and astroglia. Two evolutionally conserved enhancers, SRR1 and SRR2, are involved in controlling SOX2 expression during neurodevelopment; however, the molecular mechanisms regulating their activity are not known. We have examined DNA methylation and histone H3 acetylation at both enhancers in NT2-D1 progenitors, neurons and astrocytes, to establish the role of… CONTINUE READING
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