Epigenetic modifications in pluripotent and differentiated cells

@article{Meissner2010EpigeneticMI,
  title={Epigenetic modifications in pluripotent and differentiated cells},
  author={A. Meissner},
  journal={Nature Biotechnology},
  year={2010},
  volume={28},
  pages={1079-1088}
}
  • A. Meissner
  • Published 2010
  • Biology, Medicine
  • Nature Biotechnology
  • Epigenetic modifications constitute a complex regulatory layer on top of the genome sequence. Pluripotent and differentiated cells provide a powerful system for investigating how the epigenetic code influences cellular fate. High-throughput sequencing of these cell types has yielded DNA methylation maps at single-nucleotide resolution and many genome-wide chromatin maps. In parallel to epigenome mapping efforts, remarkable progress has been made in our ability to manipulate cell states; ectopic… CONTINUE READING
    367 Citations

    Figures and Topics from this paper

    Navigating the epigenetic landscape of pluripotent stem cells
    • 109
    • PDF
    Epigenetic regulation of open chromatin in pluripotent stem cells.
    • 16
    Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
    • 90
    • PDF
    Epigenetic landscape of pluripotent stem cells.
    • 30
    The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells
    • 40
    • PDF
    Transcriptional and epigenetic control in mouse pluripotency: lessons from in vivo and in vitro studies.
    • 9
    Chromatin states in pluripotent, differentiated, and reprogrammed cells.
    • 150
    • PDF

    References

    SHOWING 1-10 OF 154 REFERENCES
    Genetic and Epigenetic Regulators of Pluripotency
    • 564
    Global transcription in pluripotent embryonic stem cells.
    • 598
    • PDF
    Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer.
    • 282
    Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • 2,297
    • PDF
    Chromatin modification and epigenetic reprogramming in mammalian development
    • E. Li
    • Biology, Medicine
    • Nature Reviews Genetics
    • 2002
    • 1,819
    • PDF
    Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
    • 3,843
    • PDF
    Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
    • 302