Epigenetic modifications in pluripotent and differentiated cells
@article{Meissner2010EpigeneticMI, title={Epigenetic modifications in pluripotent and differentiated cells}, author={A. Meissner}, journal={Nature Biotechnology}, year={2010}, volume={28}, pages={1079-1088} }
Epigenetic modifications constitute a complex regulatory layer on top of the genome sequence. Pluripotent and differentiated cells provide a powerful system for investigating how the epigenetic code influences cellular fate. High-throughput sequencing of these cell types has yielded DNA methylation maps at single-nucleotide resolution and many genome-wide chromatin maps. In parallel to epigenome mapping efforts, remarkable progress has been made in our ability to manipulate cell states; ectopic… CONTINUE READING
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