Epigenetic modifications in pluripotent and differentiated cells

  title={Epigenetic modifications in pluripotent and differentiated cells},
  author={Alexander Meissner},
  journal={Nature Biotechnology},
  • A. Meissner
  • Published 1 October 2010
  • Biology
  • Nature Biotechnology
Epigenetic modifications constitute a complex regulatory layer on top of the genome sequence. Pluripotent and differentiated cells provide a powerful system for investigating how the epigenetic code influences cellular fate. High-throughput sequencing of these cell types has yielded DNA methylation maps at single-nucleotide resolution and many genome-wide chromatin maps. In parallel to epigenome mapping efforts, remarkable progress has been made in our ability to manipulate cell states; ectopic… 

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