Epigenetic modifications in double-strand break DNA damage signaling and repair.

  title={Epigenetic modifications in double-strand break DNA damage signaling and repair.},
  author={Dorine Rossetto and Andrew W Truman and Stephen J. Kron and Jacques C{\^o}t{\'e}},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={16 18},
Factors involved in the cellular response to double-strand break (DSB) DNA damage have been identified as potential therapeutic targets that would greatly sensitize cancer cells to radiotherapy and genotoxic chemotherapy. These targets could disable the repair machinery and/or reinstate normal cell-cycle checkpoint leading to growth arrest, senescence, and apoptosis. It is now clear that a major aspect of the DNA damage response occurs through specific interactions with chromatin structure and… CONTINUE READING
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