Epigenetic modifications during oocyte growth correlates with extended parthenogenetic development in the mouse

@article{Kono1996EpigeneticMD,
  title={Epigenetic modifications during oocyte growth correlates with extended parthenogenetic development in the mouse},
  author={Tomohiro Kono and Yayoi Obata and Tomomi Yoshimzu and Tatsuo Nakahara and John R. Carroll},
  journal={Nature Genetics},
  year={1996},
  volume={13},
  pages={91-94}
}
In mammals, the maternal and paternal genomes are required for embryonic development1–5. This is due to genomic imprinting which leads to the expression or repression of genes solely on the basis of the parent from which they were inherited6–9 As a result, parthenogenetic embryos die before day 10 of gestation and show limited development of extra-embryonic membranes3,4. Maternal imprinting is established during oogenesis6–11 and is associated with allele specific modifications in DMA… CONTINUE READING