Epigenetic modifications and human disease

  title={Epigenetic modifications and human disease},
  author={A. Portela and M. Esteller},
  journal={Nature Biotechnology},
  • A. Portela, M. Esteller
  • Published 2010
  • Biology, Medicine
  • Nature Biotechnology
  • Epigenetics is one of the most rapidly expanding fields in biology. The recent characterization of a human DNA methylome at single nucleotide resolution, the discovery of the CpG island shores, the finding of new histone variants and modifications, and the unveiling of genome-wide nucleosome positioning maps highlight the accelerating speed of discovery over the past two years. Increasing interest in epigenetics has been accompanied by technological breakthroughs that now make it possible to… CONTINUE READING
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