Epigenetic modification of spinal miR-219 expression regulates chronic inflammation pain by targeting CaMKIIγ.

@article{Pan2014EpigeneticMO,
  title={Epigenetic modification of spinal miR-219 expression regulates chronic inflammation pain by targeting CaMKIIγ.},
  author={Zhiqiang Pan and Li-Jiao Zhu and Yan-Qiang Li and Ling-Yun Hao and Cui Yin and Jun-Xia Yang and Yubai Guo and Song Zhang and Lu Hua and Zhou-Ya Xue and Hong-Xing Zhang and Jun-li Cao},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 29},
  pages={9476-83}
}
Emerging evidence has shown that miRNA-mediated gene expression modulation contributes to chronic pain, but its functional regulatory mechanism remains unknown. Here, we found that complete Freund's adjuvant (CFA)-induced chronic inflammation pain significantly reduced miRNA-219 (miR-219) expression in mice spinal neurons. Furthermore, the expression of spinal CaMKIIγ, an experimentally validated target of miR-219, was increased in CFA mice. Overexpression of spinal miR-219 prevented and… CONTINUE READING
23 Citations
27 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

MicroRNA-mediated GABA

  • A Miranda, R Shaker, B Banerjee
  • 2013

Similar Papers

Loading similar papers…