Epigenetic mechanisms underlying arsenic-induced toxicity

  title={Epigenetic mechanisms underlying arsenic-induced toxicity},
  author={Cassandra J. Meakin and Elizabeth Mar{\'i}n Mart{\'i}n and Rebecca C Fry},
Abstract Millions of individuals world-wide are exposed to potentially harmful levels of inorganic arsenic that exceed the World Health Organization (WHO) recommended limit of 10 μg/L. To date, studies on inorganic arsenic-associated epigenetic modifications suggest numerous mechanisms by which inorganic arsenic impacts DNA methylation, miRNA expression, and histones. For example, evidence supports that inorganic arsenic modifies the enzymatic activity of DNA methyltransferases, histone… CONTINUE READING