Epigenetic mechanisms of chemical carcinogenesis.

  title={Epigenetic mechanisms of chemical carcinogenesis.},
  author={James E Klaunig and Lisa M. Kamendulis and Yuanyuan Xu},
  journal={Human & experimental toxicology},
  volume={19 10},
Chemically induced cancer is a multi-step process involving damage to the genome initially followed by clonal expansion of the DNA damaged cell eventually leading to a neoplasm. Chemical carcinogens have been shown to impact at all of the stages of the tumorigenesis process. It has become apparent that chemical and physical agents that induce cancer may do so through several different cellular and molecular mechanisms. Epigenetic (nongenotoxic) chemical carcinogens are those agents that… CONTINUE READING

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