Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene.

@article{Cao2010EpigeneticMM,
  title={Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene.},
  author={Yuxia X Cao and Tiffany N. Vo and Guetchyn Millien and J Tagne and Darrell N. Kotton and Robert J. Mason and Mary C. Williams and Maria I Ramirez},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 3},
  pages={2152-64}
}
Epigenetic regulation of transcription plays an important role in cell-specific gene expression by altering chromatin structure and access of transcriptional regulators to DNA binding sites. Surfactant protein B (Sftpb) is a developmentally regulated lung epithelial gene critical for lung function. Thyroid transcription factor 1 (Nkx2-1) regulates Sftpb gene expression in various species. We show that Nkx2-1 binds to the mouse Sftpb (mSftpb) promoter in the lung. In a mouse lung epithelial cell… CONTINUE READING
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