Epigenetic mechanisms in neurological disease

@article{Jakovcevski2012EpigeneticMI,
  title={Epigenetic mechanisms in neurological disease},
  author={Mira Jakovcevski and Schahram Akbarian},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={1194-1204}
}
The exploration of brain epigenomes, which consist of various types of DNA methylation and covalent histone modifications, is providing new and unprecedented insights into the mechanisms of neural development, neurological disease and aging. Traditionally, chromatin defects in the brain were considered static lesions of early development that occurred in the context of rare genetic syndromes, but it is now clear that mutations and maladaptations of the epigenetic machinery cover a much wider… CONTINUE READING
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