Epigenetic mechanisms in neurological disease

  title={Epigenetic mechanisms in neurological disease},
  author={Mira Jakovcevski and Schahram Akbarian},
  journal={Nature Medicine},
The exploration of brain epigenomes, which consist of various types of DNA methylation and covalent histone modifications, is providing new and unprecedented insights into the mechanisms of neural development, neurological disease and aging. Traditionally, chromatin defects in the brain were considered static lesions of early development that occurred in the context of rare genetic syndromes, but it is now clear that mutations and maladaptations of the epigenetic machinery cover a much wider… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS
142 Citations
155 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 142 extracted citations


Publications referenced by this paper.
Showing 1-10 of 155 references

Crh and Oprm 1 mediate anxietyrelated behavior and social approach in a mouse model of MECP 2 duplication syndrome

  • R. C. Samaco
  • Nat . Genet .
  • 2012

Rett syndrome mutation MeCP 2 T 158 A disrupts DNA binding , protein stability and ERP responses

  • D. Goffin
  • Nat . Neurosci .
  • 2012

Similar Papers

Loading similar papers…