Epigenetic mechanisms in cardiac development and disease.

  title={Epigenetic mechanisms in cardiac development and disease.},
  author={Marcus Vallaster and Caroline S Dacwag Vallaster and Sean M Wu},
  journal={Acta biochimica et biophysica Sinica},
  volume={44 1},
During mammalian development, cardiac specification and ultimately lineage commitment to a specific cardiac cell type is accomplished by the action of specific transcription factors (TFs) and their meticulous control on an epigenetic level. In this review, we detail how cardiac-specific TFs function in concert with nucleosome remodeling and histone-modifying enzymes to regulate a diverse network of genes required for processes such as cell growth and proliferation, or epithelial to mesenchymal… CONTINUE READING
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