Epigenetic interplay between histone modifications and DNA methylation in gene silencing.

  title={Epigenetic interplay between histone modifications and DNA methylation in gene silencing.},
  author={Thomas Vaissi{\`e}re and Carla Sawan and Zdenko Herceg},
  journal={Mutation research},
  volume={659 1-2},
Knowledge on heritable changes in gene expression that result from epigenetic events is of increasing relevance in the development of strategies for prevention, early diagnosis and treatment of cancer. Histone acetylation and DNA methylation are epigenetic modifications whose patterns can be regarded as heritable marks that ensure accurate transmission of the chromatin states and gene expression profiles over many cell generations. Importantly, patterns and levels of DNA methylation and histone… CONTINUE READING
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