Epigenetic inheritance of fetal genes in allergic asthma.

@article{Bousquet2004EpigeneticIO,
  title={Epigenetic inheritance of fetal genes in allergic asthma.},
  author={Jean Bousquet and William Jacot and Hans Yssel and Antonio Maurizio Vignola and Marc Humbert},
  journal={Allergy},
  year={2004},
  volume={59 2},
  pages={
          138-47
        }
}
Asthma has been associated with an exaggerated T-helper type 2 (Th2) over Th1 responses to allergic and nonallergic stimuli, which leads to chronic airway inflammation and airway remodeling. In the present article, we propose that many of the genes involved in IgE synthesis and airways (re)modeling in asthma are persistent or reminiscent fetal genes which may not be silenced during early infancy (or late pregnancy). Genes of the embryologic differentiation of ectodermic and endodermic tissues… CONTINUE READING
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