Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

  title={Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications},
  author={Qi Chen and Wei Yan and Enkui Duan},
  journal={Nature Reviews Genetics},
Once deemed heretical, emerging evidence now supports the notion that the inheritance of acquired characteristics can occur through ancestral exposures or experiences and that certain paternally acquired traits can be 'memorized' in the sperm as epigenetic information. The search for epigenetic factors in mammalian sperm that transmit acquired phenotypes has recently focused on RNAs and, more recently, RNA modifications. Here, we review insights that have been gained from studying sperm RNAs… CONTINUE READING

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