Epigenetic inheritance during the cell cycle

  title={Epigenetic inheritance during the cell cycle},
  author={Aline V. Probst and Elaine M. Dunleavy and Genevi{\`e}ve Almouzni},
  journal={Nature Reviews Molecular Cell Biology},
Studies that concern the mechanism of DNA replication have provided a major framework for understanding genetic transmission through multiple cell cycles. Recent work has begun to gain insight into possible means to ensure the stable transmission of information beyond just DNA, and has led to the concept of epigenetic inheritance. Considering chromatin-based information, key candidates have arisen as epigenetic marks, including DNA and histone modifications, histone variants, non-histone… 
Chromatin structure and the inheritance of epigenetic information
The multiple mechanisms that potentially affect the inheritance of epigenetic information in somatic cells are reviewed and the importance of positive-feedback loops, long-range gene interactions and the complex network of trans-acting factors in the transmission of chromatin states is discussed.
Epigenetic dynamics across the cell cycle.
This chapter summarizes the current knowledge on the dynamics of epigenetic chromatin modifications during progression of the cell cycle and regulates cell-cycle progression locally and globally by controlling chromatin condensation and chromosome segregation.
Chromatin replication and epigenetic cell memory
Recent advances in chromatin replication and maintenance across mitotic division are discussed, with emphasis on replication-coupled chromatin assembly and chromatin maturation post-replication.
DNA replication components as regulators of epigenetic inheritance—lesson from fission yeast centromere
Recent advances on the role of DNA replication components in the inheritance of epigenetic marks are discussed, with a particular focus on epigenetic regulation in fission yeast.
Stable transmission of reversible modifications: maintenance of epigenetic information through the cell cycle
In this review, DNA methylation and histone methylation by specific histone lysine methyltransferases (KMT) and the Polycomb/Trithorax proteins are considered as the primary mediators of epigenetic inheritance.
Preservation of Epigenetic Memory During DNA Replication.
Little is known about how the recruitment of critical chromatin modifying enzymes changes during stem cell differentiation, and this question is especially pertinent due to the recent emphasis on cell reprogramming for regenerative medicine.
The coupling of epigenome replication with DNA replication.
Chromatin replication and epigenome maintenance
Stability and function of eukaryotic genomes are closely linked to chromatin structure and organization, and if DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism.
Mechanisms of epigenetic inheritance: Copying of Polycomb repressed chromatin
These studies suggest that both segregation of chromatin features to newly replicated chromatin and a feedback loop consisting of histone modification and recognition of this modification may contribute to inheritance.


Epigenomic replication: linking epigenetics to DNA replication.
Several recent studies report the localization of certain chromatin modifying proteins to replication forks at specific times during S-phase, suggesting that spatiotemporal regulation of chromatin assembly proteins may be an integral part of epigenetic inheritance.
PCNA, the Maestro of the Replication Fork
The inheritance of epigenetic defects.
It is proposed that epigenetic defects in germline cells due to loss of methylation can be repaired by recombination at meiosis but that some are transmitted to offspring.
Marking histone H3 variants: how, when and why?
Stability and flexibility of epigenetic gene regulation in mammalian development
During development, cells start in a pluripotent state, from which they can differentiate into many cell types, and progressively develop a narrower potential. Their gene-expression programmes become
Chromatin dynamics during epigenetic reprogramming in the mouse germ line
It is suggested that the mechanism of histone replacement is critical for these chromatin rearrangements to occur, and the marked chromatin changes are intimately linked with genome-wide DNA demethylation.