Epigenetic inheritance during the cell cycle

@article{Probst2009EpigeneticID,
  title={Epigenetic inheritance during the cell cycle},
  author={Aline V. Probst and Elaine M. Dunleavy and Genevi{\`e}ve Almouzni},
  journal={Nature Reviews Molecular Cell Biology},
  year={2009},
  volume={10},
  pages={192-206}
}
Studies that concern the mechanism of DNA replication have provided a major framework for understanding genetic transmission through multiple cell cycles. Recent work has begun to gain insight into possible means to ensure the stable transmission of information beyond just DNA, and has led to the concept of epigenetic inheritance. Considering chromatin-based information, key candidates have arisen as epigenetic marks, including DNA and histone modifications, histone variants, non-histone… 
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References

SHOWING 1-10 OF 189 REFERENCES
Chromatin Challenges during DNA Replication and Repair
Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information.
Epigenomic replication: linking epigenetics to DNA replication.
TLDR
Several recent studies report the localization of certain chromatin modifying proteins to replication forks at specific times during S-phase, suggesting that spatiotemporal regulation of chromatin assembly proteins may be an integral part of epigenetic inheritance.
Histone variants, nucleosome assembly and epigenetic inheritance.
PCNA, the Maestro of the Replication Fork
Replication-Dependent Marking of DNA by PCNA Facilitates CAF-1-Coupled Inheritance of Chromatin
The inheritance of epigenetic defects.
TLDR
It is proposed that epigenetic defects in germline cells due to loss of methylation can be repaired by recombination at meiosis but that some are transmitted to offspring.
Marking histone H3 variants: how, when and why?
Stability and flexibility of epigenetic gene regulation in mammalian development
During development, cells start in a pluripotent state, from which they can differentiate into many cell types, and progressively develop a narrower potential. Their gene-expression programmes become…
Chromatin dynamics during epigenetic reprogramming in the mouse germ line
TLDR
It is suggested that the mechanism of histone replacement is critical for these chromatin rearrangements to occur, and the marked chromatin changes are intimately linked with genome-wide DNA demethylation.
...
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