Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma.

@article{Marsit2006EpigeneticIO,
  title={Epigenetic inactivation of the SFRP genes is associated with drinking, smoking and HPV in head and neck squamous cell carcinoma.},
  author={Carmen J. Marsit and Michael D Mcclean and C. Sloane Furniss and Karl T. Kelsey},
  journal={International journal of cancer},
  year={2006},
  volume={119 8},
  pages={
          1761-6
        }
}
The soluble frizzled receptor protein (SFRP) family encodes antagonists of the WNT pathway, and silencing of these genes, through promoter hypermethylation, leads to constitutive WNT signaling. In bladder cancers, hypermethylation of the SFRP genes occurs more often in current and former smokers and is a strong predictor of poor patient survival. Hence, we examined methylation of these genes in another tobacco-related epithelial cancer, head and neck squamous cell carcinoma (HNSCC), to… CONTINUE READING

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