Epigenetic inactivation of the RUNX3 gene in lung cancer.

  title={Epigenetic inactivation of the RUNX3 gene in lung cancer.},
  author={Koji Sato and Yoshio Tomizawa and Hironobu Iijima and Ryusei Saito and Tamotsu Ishizuka and Takashi Nakajima and Masatomo Mori},
  journal={Oncology reports},
  volume={15 1},
The silencing of tumor suppressor genes (TSGs) by aberrant hypermethylation occurs frequently in human cancer. Recently the RUNX3 gene was identified as a TSG inactivated by hypermethylation. We examined RUNX3 expression by reverse transcription-PCR and the methylation status of this gene by methylation specific-PCR in 43 lung cancer cell lines and 120 primary non-small cell lung cancer (NSCLC) tumor samples. RUNX3 expression was absent in 10 (50%) of 20 small cell lung cancer (SCLC) cell lines… CONTINUE READING


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High-density methylation of p14(ARF) and p16(INK4A) in epstein-Bar virus-associated gastric carcinoma

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