Epigenetic inactivation of the MIR34B/C in multiple myeloma.

  title={Epigenetic inactivation of the MIR34B/C in multiple myeloma.},
  author={Kwan Yeung Wong and Rita Lok Hay Yim and C. K. So and Dong-Yan Jin and Raymond Liang and Chor Sang Chim},
  volume={118 22},
We postulated that MIR34B/C, a direct transcriptional target of TP53, might be inactivated by promoter hypermethylation in multiple myeloma (MM). MIR34B/C promoter methylation was studied in 8 normal marrow controls, 8 MM cell lines, 95 diagnostic, and 23 relapsed/progressed MM samples by methylation-specific PCR. MIR34B/C was methylated in 6 (75.0%) MM cell lines but not normal controls. 5-Aza-2'-deoxycytidine led to MIR34B/C promoter demethylation and MIR34B reexpression. Moreover… CONTINUE READING
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