Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer.

@article{Lehmann2008EpigeneticIO,
  title={Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer.},
  author={Ulrich Lehmann and Britta Hasemeier and Matthias Christgen and Markus S. Mueller and Daniel R{\"o}mermann and Florian L{\"a}nger and Hans Kreipe},
  journal={The Journal of pathology},
  year={2008},
  volume={214 1},
  pages={17-24}
}
MicroRNAs (miRNAs) represent a new class of small non-coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA expression has been described for several human malignancies and tumour suppressor functions have been ascribed to this new class of small regulatory RNAs. Accordingly, inactivation due to deletion or mutation has been found in human malignancies. Here, we describe the role of aberrant hypermethylation as an additional mechanism… CONTINUE READING