Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

@article{Suzuki2004EpigeneticIO,
  title={Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer},
  author={Hiromu Suzuki and D Neil Watkins and Kam-wing Jair and Kornel E. Schuebel and Sanford D Markowitz and Wei Dong Chen and Theresa P. Pretlow and Bin Yang and Yoshimitsu Akiyama and Manon van Engeland and Minoru Toyota and Takashi Tokino and Yuji Hinoda and Kohzoh Imai and James G. Herman and Stephen B. Baylin},
  journal={Nature Genetics},
  year={2004},
  volume={36},
  pages={417-422}
}
Aberrant WNT pathway signaling is an early progression event in 90% of colorectal cancers. It occurs through mutations mainly of APC and less often of CTNNB1 (encoding β-catenin) or AXIN2 (encoding axin-2, also known as conductin). These mutations allow ligand-independent WNT signaling that culminates in abnormal accumulation of free β-catenin in the nucleus. We previously identified frequent promoter hypermethylation and gene silencing of the genes encoding secreted frizzled-related proteins… CONTINUE READING
Highly Influential
This paper has highly influenced 37 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS