Epigenetic inactivation and tumor suppressor activity of HAI-2/SPINT2 in gastric cancer.

Abstract

Hepatocyte growth factor (HGF) activator inhibitor type 2 (HAI-2/SPINT2) encodes Kunitz-type protease inhibitor that regulates HGF activity. Inspection of the human HAI-2/SPINT2 locus uncovered a large and dense CpG island within the 5' region of this gene. Analysis of cultured human gastric tumor lines indicated that HAI-2/SPINT2 expression is either… (More)
DOI: 10.1002/ijc.25161

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