Epigenetic imprinting by commensal probiotics inhibits the IL-23/IL-17 axis in an in vitro model of the intestinal mucosal immune system.

@article{Ghadimi2012EpigeneticIB,
  title={Epigenetic imprinting by commensal probiotics inhibits the IL-23/IL-17 axis in an in vitro model of the intestinal mucosal immune system.},
  author={Darab Ghadimi and Ulf Helwig and J{\"u}rgen Schrezenmeir and Knut J. Heller and Michael de Vrese},
  journal={Journal of leukocyte biology},
  year={2012},
  volume={92 4},
  pages={895-911}
}
The pathophysiology of IBD is characterized by a complex interaction between genes and the environment. Genetic and environmental differences are attributed to the heterogeneity of the disease pathway and to the epigenetic modifications that lead to altered gene expression in the diseased tissues. The epigenetic machinery consists of short interfering RNA, histone modifications, and DNA methylation. We evaluated the effects of Bifidobacterium breve (DSMZ 20213) and LGG (ATCC 53103), as… CONTINUE READING
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