Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells.

@article{Murata2012EpigeneticHM,
  title={Epigenetic histone modification of Epstein-Barr virus BZLF1 promoter during latency and reactivation in Raji cells.},
  author={Takayuki Murata and Yutaka Kondo and Atsuko Sugimoto and Daisuke Kawashima and Shinichi Saito and Hiroki Isomura and Teru Kanda and Tatsuya Tsurumi},
  journal={Journal of virology},
  year={2012},
  volume={86 9},
  pages={4752-61}
}
The Epstein-Barr virus (EBV) predominantly establishes latent infection in B cells, and the reactivation of the virus from latency is dependent on the expression of the viral BZLF1 protein. The BZLF1 promoter (Zp) normally exhibits only low basal activity but is activated in response to chemical or biological inducers, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), calcium ionophores, or histone deacetylase (HDAC) inhibitors. In some cell lines latently infected with EBV, an HDAC inhibitor… CONTINUE READING

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