Epigenetic histone methylation modulates fibrotic gene expression.

  title={Epigenetic histone methylation modulates fibrotic gene expression.},
  author={Guangdong Sun and Marpadga Amarender Reddy and Hang Yuan and Linda L. Lanting and Mitsuo Kato and Rama Natarajan},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 12},
TGF-β1-induced expression of extracellular matrix (ECM) genes plays a major role in the development of chronic renal diseases such as diabetic nephropathy. Although many key transcription factors are known, mechanisms involving the nuclear chromatin that modulate ECM gene expression remain unclear. Here, we examined the role of epigenetic chromatin marks such as histone H3 lysine methylation (H3Kme) in TGF-β1-induced gene expression in rat mesangial cells under normal and high-glucose (HG… CONTINUE READING