Epigenetic heredity: RNA‐mediated modes of phenotypic variation

@article{Rassoulzadegan2015EpigeneticHR,
  title={Epigenetic heredity: RNA‐mediated modes of phenotypic variation},
  author={Minoo Rassoulzadegan and François Cuzin},
  journal={Annals of the New York Academy of Sciences},
  year={2015},
  volume={1341}
}
In addition to the Mendelian mutations, several instances of heritable phenotypic variation have been reported. We have observed, in mice, a role for sperm RNAs in the induction of such stable phenotypic variation. When experimentally transferred by RNA microinjection into fertilized mouse eggs, the noncoding RNAs homologous in sequence to the target locus are efficient inducers of variation at the transcriptional level. Transmission of the phenotypic variation to progeny is highly efficient… 
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