Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

@article{Baylin2006EpigeneticGS,
  title={Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?},
  author={S. Baylin and J. Ohm},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={107-116}
}
Chromatin alterations have been associated with all stages of tumour formation and progression. The best characterized are epigenetically mediated transcriptional-silencing events that are associated with increases in DNA methylation — particularly at promoter regions of genes that regulate important cell functions. Recent evidence indicates that epigenetic changes might 'addict' cancer cells to altered signal-transduction pathways during the early stages of tumour development. Dependence on… Expand

Paper Mentions

Interventional Clinical Trial
A pilot study of colorectal cancer screening using stool DNA-based SDC2 methylation test  
ConditionsColon Polyp, Colorectal Cancer, Healthy
InterventionDiagnostic Test
Cancer epigenetics: from disruption of differentiation programs to the emergence of cancer stem cells.
The epigenetics of breast cancer
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Epigenetic aberrations during oncogenesis
Epigenetic inactivation of DNA repair in breast cancer.
The Genetic-Epigenetic Interplay in Cancer
The cancer epigenome--components and functional correlates.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 129 REFERENCES
The fundamental role of epigenetic events in cancer
Epigenetics and cancer.
Cancer-epigenetics comes of age
Gene silencing in cancer in association with promoter hypermethylation.
Distinct epigenetic changes in the stromal cells of breast cancers
...
1
2
3
4
5
...