Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?
@article{Baylin2006EpigeneticGS, title={Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?}, author={Stephen B. Baylin and Joyce Ellen Ohm}, journal={Nature Reviews Cancer}, year={2006}, volume={6}, pages={107-116} }
Chromatin alterations have been associated with all stages of tumour formation and progression. The best characterized are epigenetically mediated transcriptional-silencing events that are associated with increases in DNA methylation — particularly at promoter regions of genes that regulate important cell functions. Recent evidence indicates that epigenetic changes might 'addict' cancer cells to altered signal-transduction pathways during the early stages of tumour development. Dependence on…
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