Epigenetic gene silencing in cancer: the DNA hypermethylome.

  title={Epigenetic gene silencing in cancer: the DNA hypermethylome.},
  author={Manel Esteller},
  journal={Human molecular genetics},
  volume={16 Spec No 1},
Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of the best-known lesions of the malignant cell is the transcriptional repression of tumor-suppressor genes by promoter CpG island hypermethylation. We are in the process of completing the molecular dissection of the entire epigenetic machinery involved in methylation-associated silencing, such as DNA methyltransferases, methyl-CpG binding domain proteins, histone deacetylases, histone methyltransferases… CONTINUE READING
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