Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation.

Abstract

Brain-derived neurotrophic factor (bdnf) is one of numerous gene products necessary for long-term memory formation and dysregulation of bdnf has been implicated in the pathogenesis of cognitive and mental disorders. Recent work indicates that epigenetic-regulatory mechanisms including the markings of histone proteins and associated DNA remain labile… (More)
DOI: 10.1016/j.nlm.2011.03.001

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