Epigenetic factors and midbrain dopaminergic neurone development.

  title={Epigenetic factors and midbrain dopaminergic neurone development.},
  author={Carla Perrone-Capano and Umberto di Porzio},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={18 10},
In the mammalian brain dopamine systems play a central role in the control of movement, hormone release, emotional balance and reward. Alteration of dopaminergic neurotransmission is involved in Parkinson's disease and other movement disorders, as well as in some psychotic syndromes. This review summarises recent findings, which shed some light on signals and cellular interactions involved in the specification and maturation of the dopaminergic function during neurogenesis. In particular we… CONTINUE READING