Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions.

@article{Ramrez2008EpigeneticEI,
  title={Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions.},
  author={Natalia Ram{\'i}rez and Eva Bandr{\'e}s and Alfons Navarro and Antoine Pons and S M P J Jansa and I. Romero Moreno and Francisco Mart{\'i}nez-R{\'o}denas and Ruth Z{\'a}rate and Nerea Bitarte and M Monzo and Jes{\'u}s Miguel Garc{\'i}a-Foncillas},
  journal={European journal of cancer},
  year={2008},
  volume={44 17},
  pages={2689-95}
}
Gene inactivation by promoter hypermethylation has been demonstrated in the colonic mucosa of colorectal cancer (CRC) patients. However, current data do not prove direct involvement of this epigenetic modification in the early stages of CRC. Promoter methylation profiles of E-cadherin, hMLH1, MGMT, p16(INK4a), p15(INK4b) and p14(ARF); mutations of K-ras, B-raf and TP53 and microsatellite instability (MSI) were examined in normal and cancerous colonic mucosal tissue in 82 CRC patients using… CONTINUE READING