Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function.

@article{Bergmann2012EpigeneticEH,
  title={Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function.},
  author={Jan H. Bergmann and Julia N. Jakubsche and Nuno M. C. Martins and Alexander Kagansky and Megumi Nakano and Hiroshi Kimura and David A. Kelly and Bryan M. Turner and Hiroshi Masumoto and Vladimir L. Larionov and William C Earnshaw},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 2},
  pages={411-21}
}
Human kinetochores are transcriptionally active, producing very low levels of transcripts of the underlying alpha-satellite DNA. However, it is not known whether kinetochores can tolerate acetylated chromatin and the levels of transcription that are characteristic of housekeeping genes, or whether kinetochore-associated 'centrochromatin', despite being transcribed at a low level, is essentially a form of repressive chromatin. Here, we have engineered two types of acetylated chromatin within the… CONTINUE READING

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A super-resolution map of the vertebrate kinetochore.

Proceedings of the National Academy of Sciences of the United States of America • 2010
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