Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.

@article{Lewis2006EpigeneticDO,
  title={Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.},
  author={Annabelle Lewis and Kelly Green and Claire Dawson and Lisa Redrup and Khanh D. Huynh and Jeannie T Lee and Myriam Hemberger and Wolf Reik},
  journal={Development},
  year={2006},
  volume={133 21},
  pages={4203-10}
}
The mouse Kcnq1 imprinted domain is located on distal chromosome 7 and contains several imprinted genes that are paternally repressed. Repression of these genes is regulated by a non-coding antisense transcript, Kcnq1ot1, which is paternally expressed. Maternal repression of Kcnq1ot1 is controlled by DNA methylation originating in the oocyte. Some genes in the region are imprinted only in the placenta, whereas others are imprinted in both extra-embryonic and embryonic lineages. Here, we show… CONTINUE READING

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