Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal

@article{Hemberger2009EpigeneticDO,
  title={Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal},
  author={Myriam Hemberger and Wendy Dean and Wolf Reik},
  journal={Nature Reviews Molecular Cell Biology},
  year={2009},
  volume={10},
  pages={526-537}
}
Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early development, this heterogeneity of epigenetic states is associated with stochastic expression of lineage-determining transcription factors that establish an intimate crosstalk with epigenetic modifiers. Lineage-specific epigenetic modification of crucial transcription factor loci (for example, methylation of the Elf5… CONTINUE READING
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