Epigenetic dynamics of monocyte-to-macrophage differentiation

@inproceedings{Wallner2016EpigeneticDO,
  title={Epigenetic dynamics of monocyte-to-macrophage differentiation},
  author={Stefan Wallner and Christopher Schr{\"o}der and Elsa Leit{\~a}o and Tea Berulava and Claudia Haak and Daniela Beisser and Sven Rahmann and Andreas S. Richter and Thomas Manke and Ulrike Boenisch and Laura Arrigoni and Sebastian Fr{\"o}hler and Filippos Klironomos and Wei Yea Chen and Nikolaus Rajewsky and Fabian M{\"u}ller and Peter Ebert and Thomas Lengauer and Matthias Barann and Philip Rosenstiel and Gilles Gasparoni and Karl Nordstr{\"o}m and J{\"o}rn Walter and Benedikt Brors and Gideon Zipprich and Baerbel Felder and Ludger Klein-Hitpass and Corinna Attenberger and Gerd Schmitz and Bernhard Horsthemke},
  booktitle={Epigenetics & Chromatin},
  year={2016}
}
Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to analyze the complete transcriptome and epigenome of human monocytes that were differentiated in vitro by addition of colony-stimulating factor 1 in serum-free medium. Numerous mRNAs and miRNAs were significantly up- or down-regulated. More than 100 discrete DNA regions, most often far away… CONTINUE READING
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