Epigenetic down regulation of nerve growth factor during alcohol withdrawal

@article{Heberlein2013EpigeneticDR,
  title={Epigenetic down regulation of nerve growth factor during alcohol withdrawal},
  author={Annemarie Heberlein and Marc An Muschler and Helge Frieling and M Behr and Christian K. Eberlein and Julia Wilhelm and Michael Gr{\"o}schl and Johannes Kornhuber and Stefan Bleich and Thomas Hillemacher},
  journal={Addiction Biology},
  year={2013},
  volume={18}
}
We investigated the Cytosin‐phosphatidyl‐Guanin (CpG) island promoter methylation (mean and methylation of individual CpG‐sites) of the nerve growth factor (NGF) gene in the blood of alcohol‐dependent patients (57 male patients) during withdrawal (days 1, 7 and 14). Methylation and NGF serum levels did not change significantly from days 1–7. From days 7–14, mean methylation increased (F = 30.55, P < 0.001), whereas the NGF serum levels decreased significantly (days 7–14: F = 17.95, P < 0.001… 
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