Epigenetic down-regulation of death-associated protein kinase in lung cancers.


PURPOSE Death-associated protein kinase (DAPK) is a pro-apoptotic serine/threonine kinase involved in apoptosis. Aberrant methylation of DAPK was reported in lung cancers by methylation-specific PCR. However, we were unable to relate methylation with gene silencing with the same methodology. Our goals were to develop a methodology that related methylation… (More)


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@article{Toyooka2003EpigeneticDO, title={Epigenetic down-regulation of death-associated protein kinase in lung cancers.}, author={Shinichi Toyooka and Kiyomi O Toyooka and Kuniharu Miyajima and Jyotsna L Reddy and Minoru Toyota and Ubradka G Sathyanarayana and Asha Padar and Melvyn S. Tockman and Stephen Lam and Narayan Shivapurkar and Adi F. Gazdar}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2003}, volume={9 8}, pages={3034-41} }