Epigenetic down-regulation of ARF expression is a selection step in immortalization of human fibroblasts by c-Myc.

@article{Benanti2007EpigeneticDO,
  title={Epigenetic down-regulation of ARF expression is a selection step in immortalization of human fibroblasts by c-Myc.},
  author={Jennifer A. Benanti and Myra L Wang and Hadley E Myers and Kristin L. Robinson and Carla M. Grandori and Denise A. Galloway},
  journal={Molecular cancer research : MCR},
  year={2007},
  volume={5 11},
  pages={1181-9}
}
The transcription factor c-Myc is implicated in the pathogenesis of many cancers. Among the multiple functions of c-Myc, activation of hTert and other genes involved in cellular life span contributes to its role as an oncogene. However, the ability of c-Myc to directly immortalize human cells remains controversial. We show here that overexpression of c-Myc reproducibly immortalizes freshly isolated human foreskin fibroblasts. c-Myc-immortalized cells displayed no gross karyotypic abnormalities… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Functional genomics identifies therapeutic targets for MYC-driven cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 4 Excerpts

Cellular senescence: hot or what?

Current opinion in genetics & development • 2009
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Immortalization of primary human prostate epithelial cells by c-Myc.

Cancer research • 2005
View 3 Excerpts
Highly Influenced

Transcriptional regulation and transformation by Myc proteins

Nature Reviews Molecular Cell Biology • 2005
View 2 Excerpts

Similar Papers

Loading similar papers…