Epigenetic control of sexual differentiation of the bed nucleus of the stria terminalis.

@article{Murray2009EpigeneticCO,
  title={Epigenetic control of sexual differentiation of the bed nucleus of the stria terminalis.},
  author={Elaine K. Murray and Annie Hien and G J de Vries and N G Forger},
  journal={Endocrinology},
  year={2009},
  volume={150 9},
  pages={4241-7}
}
The principal nucleus of the bed nucleus of the stria terminalis (BNSTp) is larger in volume and contains more cells in male than female mice. These sex differences depend on testosterone and arise from a higher rate of cell death during early postnatal life in females. There is a delay of several days between the testosterone surge at birth and sexually dimorphic cell death in the BNSTp, suggesting that epigenetic mechanisms may be involved. We tested the hypothesis that chromatin remodeling… CONTINUE READING
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