Epigenetic control of retrotransposon expression in human embryonic stem cells.

  title={Epigenetic control of retrotransposon expression in human embryonic stem cells.},
  author={Angela Macia and Mart{\'i}n Mu{\~n}oz-L{\'o}pez and Jos{\'e} Luis Cort{\'e}s and Robert K. Hastings and Santiago Morell and Gema Lucena-Aguilar and Juan Antonio Marchal and Richard Badge and Jose Luis Garc{\'i}a-P{\'e}rez},
  journal={Molecular and cellular biology},
  volume={31 2},
Long interspersed element 1s (LINE-1s or L1s) are a family of non-long-terminal-repeat retrotransposons that predominate in the human genome. Active LINE-1 elements encode proteins required for their mobilization. L1-encoded proteins also act in trans to mobilize short interspersed elements (SINEs), such as Alu elements. L1 and Alu insertions have been implicated in many human diseases, and their retrotransposition provides an ongoing source of human genetic diversity. L1/Alu elements are… CONTINUE READING


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