Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.

@article{Kurotaki2019EpigeneticCO,
  title={Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.},
  author={Daisuke Kurotaki and Wataru Kawase and Haruka Sasaki and Jun Nakabayashi and Akira Nishiyama and Herbert C. Morse and Keiko Ozato and Yutaka Suzuki and Tomohiko Tamura},
  journal={Blood},
  year={2019},
  volume={133 17},
  pages={
          1803-1813
        }
}
Dendritic cells (DCs), which are vital for immune responses, are derived from bone marrow hematopoietic stem cells via common DC progenitors (CDPs). DC lineage fate decisions occurring at stages much earlier than CDPs have recently been recognized, yet the mechanism remains elusive. By single-cell RNA-sequencing, in vivo cell transfer experiments, and an assay for transposase-accessible chromatin sequencing using wild-type, IRF8-GFP chimera knock-in or IRF8-knockout mice, we demonstrate that… Expand
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