Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.

@article{Zika2005EpigeneticCO,
  title={Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.},
  author={Eleni Zika and Jenny P-Y Ting},
  journal={Current opinion in immunology},
  year={2005},
  volume={17 1},
  pages={58-64}
}
Recent advances have shown the crucial role of histone-modifying enzymes in controlling gene activation and repression. This led to the 'histone code' hypothesis, which proposes that combinations of histone modifications work in concert to affect specific gene expression. Mounting evidence suggests that the class II transactivator modulates promoter accessibility by coordinating the recruitment of chromatin modifiers in a time-dependent fashion. MHC-II expression is exquisitely controlled by… CONTINUE READING

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