Epigenetic control

  title={Epigenetic control},
  author={Genevi{\`e}ve P. Delcuve and Mojgan Rastegar and James R. Davie},
  journal={Journal of Cellular Physiology},
Epigenetics refers to mitotically and/or meiotically heritable variations in gene expression that are not caused by changes in DNA sequence. Epigenetic mechanisms regulate all biological processes from conception to death, including genome reprogramming during early embryogenesis and gametogenesis, cell differentiation and maintenance of a committed lineage. Key epigenetic players are DNA methylation and histone post‐translational modifications, which interplay with each other, with regulatory… 
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Stable allelic epigenetic inheritance (SAEI) does not contradict the hereditary role of DNA, but involves additional molecular mechanisms with no or almost no limitations to their variety.
The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells
The genetics and epigenetics of embryonic stem cell self-renewal and differentiation into neural stem cells, and further into specific neuronal cell types are discussed, with a focus on histone and DNA marks.
Hormesis and epigenetics: Is there a link?
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Chromatin plasticity in pluripotent cells.
Ch chromatin plasticity and epigenetics and the mechanisms that regulate the various chromatin states are discussed, which are currently a central theme in the studies of stem cell maintenance and differentiation, and which will no doubt assist in delineating the secrets of pluripotency and self-renewal.
Epigenetic Modulations in Activated Cells Early after HIV-1 Infection and Their Possible Functional Consequences
HIV-1 infection exerts epigenetic modulations in activated cells that may lead these cells to transcriptional repression with important functional consequences, and non-stimulated cells seem to increase gene transcription after HIV-1 infected cells.
Promoter-Bound p300 Complexes Facilitate Post-Mitotic Transmission of Transcriptional Memory
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DNA methylomes, histone codes and miRNAs: tying it all together.
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
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Ras regulation of DNA-methylation and cancer.
Histones and histone modifications
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It is speculated that exposures to different environmental toxins alters long‐established epigenetic programs in the brain as well as other tissues leading to late‐onset disease.
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
The application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells is reported and it is shown that chromatin state can be read in an allele-specific manner by using single nucleotide polymorphisms.
Epigenetics of cancer progression.
Multidimensional analysis, evaluating genetic and epigenetic alterations on a global and locus-specific scale in human cancer, is imperative to understand mechanisms driving changes in gene dosage, and as a means towards identifying pathways driving cancer initiation and progression.
The dynamic epigenome and its implications in toxicology.
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    Toxicological sciences : an official journal of the Society of Toxicology
  • 2007
It is proposed that exposures to different environmental agents could lead to interindividual phenotypic diversity as well as differential susceptibility to disease and behavioral pathologies.