Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

@inproceedings{Long2013EpigeneticCA,
  title={Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates},
  author={Hannah K Long and David Sims and Andreas Heger and Neil P. Blackledge and Claudia Kutter and Megan Lynne Wright and Frank Gr{\"u}tzner and Duncan T. Odom and Roger Patient and Chris P. Ponting and Robert J Klose},
  booktitle={eLife},
  year={2013}
}
Two-thirds of gene promoters in mammals are associated with regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation on chromatin. In cold-blooded vertebrates, computational CGI predictions often reside away from gene promoters, suggesting a major divergence in gene promoter architecture across vertebrates. By experimentally identifying non-methylated DNA in the genomes of seven diverse vertebrates, we instead reveal that non… CONTINUE READING
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