Epigenetic characterization of the PBEF and TIMP-2 genes in the developing placentae of normal mice.

  title={Epigenetic characterization of the PBEF and TIMP-2 genes in the developing placentae of normal mice.},
  author={Hong-Rye Kim and R. Han and Y. Diao and Chang-Sik Park and D. Jin},
  journal={BMB reports},
  volume={44 8},
Reprogramming errors, which appear frequently in cloned animals, are reflected by aberrant gene expression. We previously reported the aberrant expression of TIMP-2 and PBEF in cloned placenta and differential expression of PBEF genes during pregnancy. To examine the epigenetic modifications that regulate dynamic gene expression in developing placentae, we herein analyzed the mRNA and protein expression levels of PBEF and TIMP-2 in the placentae of normal mice during pregnancy and then examined… Expand
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