Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

@article{Greger1989EpigeneticCM,
  title={Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma},
  author={Valerie Greger and Eberhard Passarge and Wolfgang H{\"o}pping and Elmar P. Messmer and Bernhard Horsthemke},
  journal={Human Genetics},
  year={1989},
  volume={83},
  pages={155-158}
}
Epigenetic models for tumor formation assume that oncogenic transformation results from changes in the activity of otherwise normal genes. Since gene activity can be inhibited by DNA methylation, and inactivation of tumor suppressor genes is a fundamental process in oncogenesis, we investigated the methylation status of the retinoblastoma suppressor gene (RB gene) on chromosome 13, in blood and tumor cells from 21 retinoblastoma patients. Using methylation-sensitive restriction enzymes and a… CONTINUE READING

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