Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.

@article{Lim2008EpigeneticCI,
  title={Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter.},
  author={Seung-Oe Lim and Jin-Mo Gu and M. S. Kim and Hyun-Soo Kim and Y. N. Park and C. K. Park and J. Cho and Y. M. Park and G. Jung},
  journal={Gastroenterology},
  year={2008},
  volume={135 6},
  pages={
          2128-40, 2140.e1-8
        }
}
BACKGROUND & AIMS In addition to genetic alterations, epigenetic changes underlie tumor progression and metastasis. Promoter methylation can silence tumor suppressor genes, and reactive oxygen species (ROS) promote DNA damage, although the relationship between ROS and epigenetic changes in cancer cells is not clear. We sought to determine whether ROS promote hypermethylation of the promoter region of E-cadherin, a regulator of the epithelial-to-mesenchymal transition, in hepatocellular… Expand
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