Epigenetic changes at gene promoters in response to immune activation <ce:italic>in utero</ce:italic>

@article{Tang2013EpigeneticCA,
  title={Epigenetic changes at gene promoters in response to immune activation <ce:italic>in utero</ce:italic>},
  author={Bin Tang and Haiqun Jia and Ryan J Kast and Elizabeth Anne Thomas},
  journal={Brain, Behavior, and Immunity},
  year={2013},
  volume={30},
  pages={168-175}
}
Increasing evidence suggests that maternal infection increases the risk of psychiatric disorders, such as schizophrenia and autism in offspring. However, the molecular mechanisms associated with these effects are unclear. Here, we have studied epigenetic gene regulation in mice exposed to non-specific immune activation elicited by polyI:C injection to pregnant dams. Using Western blot analysis, we detected global hypoacetylation of histone H3, at lysine residues 9 and 14, and histone H4, at… CONTINUE READING

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