Epigenetic change in pituitary tumorigenesis.

@article{Farrell2003EpigeneticCI,
  title={Epigenetic change in pituitary tumorigenesis.},
  author={William E Farrell and Richard N. Clayton},
  journal={Endocrine-related cancer},
  year={2003},
  volume={10 2},
  pages={323-30}
}
Throughout the genome CpG dinucleotides are found at one-fifth of their expected frequency and their rarity is further marked by the fact that 70% are methylated. In contrast, CpG islands (CGI), found associated with the promoters of many genes, have maintained their expected frequency of this dinucleotide, and remain unmethylated. Inappropriate methylation of CGIs is associated with histone deacetylation and gene silencing, while methylation of CpGs outside of CGIs is associated with… CONTINUE READING

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