Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma

@inproceedings{Wang2013EpigeneticCI,
  title={Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma},
  author={Yong Wang and Rui Xiang Zhang and Donglu Wu and Zhihua Lu and Wentao Sun and Yong Cai and Chunxi Wang and Jingji Jin},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2013}
}
BACKGROUND MYST1 (also known as hMOF), a member of the MYST family of histone acetyltransferases (HATs) as an epigenetic mark of active genes, is mainly responsible for histone H4K16 acetylation in the cells. Recent studies have shown that the abnormal gene expression of hMOF is involved in certain primary cancers. Here we examined the involvement of hMOF expression and histone H4K16 acetylation in primary renal cell carcinoma (RCC). Simultaneously, we investigated the correlation between the… CONTINUE READING